{"id":5317,"date":"2026-05-13T14:59:53","date_gmt":"2026-05-13T18:59:53","guid":{"rendered":"https:\/\/oge.mit.edu\/msrp\/?post_type=profiles&#038;p=5317"},"modified":"2026-10-09T11:45:17","modified_gmt":"2026-10-09T15:45:17","slug":"angela-milo","status":"publish","type":"profiles","link":"https:\/\/oge.mit.edu\/msrp\/profiles\/angela-milo\/","title":{"rendered":"Angela Milo"},"content":{"rendered":"\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-8f761849 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:100%\">\n<div class=\"wp-block-group is-nowrap is-layout-flex wp-container-core-group-is-layout-8f761849 wp-block-group-is-layout-flex\">\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"300\" height=\"300\" src=\"https:\/\/oge.mit.edu\/msrp\/wp-content\/uploads\/sites\/2\/2026\/05\/Milo-Angela-e1791560619354.jpg\" alt=\"Milo, Angela\" class=\"wp-image-5616\" \/><\/figure>\n\n\n\n<p class=\"wp-container-content-69bc4bdf wp-block-paragraph\"><strong>MIT Department: <\/strong><br>Chemistry<br><br><strong>Faculty Mentor<\/strong>: <br>Mo Movassaghi<br><br><strong>Research Supervisor: <\/strong><br>Angel Garcia-Ramirez, Kathleen Downey<br><br><strong>Undergraduate Institution:<\/strong><br>Harvey Mudd College<strong><br><\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>Biography<\/strong><\/h4>\n\n\n\n<p class=\"wp-block-paragraph\">Angela Milo is a rising junior at Harvey Mudd College studying chemistry. She is motivated by the challenge of developing reactions that are efficient and environmentally responsible. At Harvey Mudd, she explored greener solvents for teaching laboratory experiments with Professor Vosburg. In the summer of 2025, she was a Leadership Alliance Summer Undergraduate Research Fellow at Princeton University, where she worked on photothermal methods to degrade polymers with Professor Stache. In Professor Ball\u2019s lab at Pomona College, she studies click reactions to access pharmaceutically relevant structures through sulfur-fluoride exchange chemistry. This summer, in Professor Movassaghi\u2019s lab, she is synthesizing epidithiodiketopiperazines, a class of biologically active natural products. Her research experience spans organic synthesis, catalysis, and green chemistry. She has been recognized as a 2026 Astronaut Scholar and a 2024 American Chemical Society Scholar. On campus, she is involved as a teaching assistant, tutor, and serves on the student government as sustainability coordinator.<\/p>\n\n\n\n<p class=\"has-text-align-center wp-block-paragraph\"><br><strong>Synthesis of Diastereomerically Enriched Epidithiodiketopiperazines<br><\/strong>Angela Milo<sup>1<\/sup>, Angel Garcia-Ramirez<sup>2 <\/sup>and Mohammad Movassaghi<sup>2<\/sup><br><sup>1<\/sup>Department of Chemistry, Harvey Mudd College<br><sup>2<\/sup>Department of Chemistry, Massachusetts Institute of Technology<\/p>\n\n\n\n<p class=\"has-text-align-left wp-block-paragraph\"><br>Epidithiodiketopiperazines (ETPs) are a class of structurally complex natural products with diverse biological activities, including potent anticancer properties. Efficient access to stereochemically defined ETP derivatives remains important for enabling biological evaluation. Herein, we describe progress toward the synthesis of diastereomerically enriched C4-substituted ETPs through the development and scale-up of a concise synthetic route. The sequence features silyl protection, lactamization, oxidation, silylation, and sulfidation. This work has established a practical route to gram-scale quantities of ETP intermediates, with ongoing efforts focused on completing the synthesis of the target compounds and enabling future biological studies.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n","protected":false},"featured_media":5616,"template":"","profile_category":[25],"class_list":["post-5317","profiles","type-profiles","status-publish","has-post-thumbnail","hentry","profile_category-2026-interns"],"acf":[],"_links":{"self":[{"href":"https:\/\/oge.mit.edu\/msrp\/wp-json\/wp\/v2\/profiles\/5317","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/oge.mit.edu\/msrp\/wp-json\/wp\/v2\/profiles"}],"about":[{"href":"https:\/\/oge.mit.edu\/msrp\/wp-json\/wp\/v2\/types\/profiles"}],"version-history":[{"count":4,"href":"https:\/\/oge.mit.edu\/msrp\/wp-json\/wp\/v2\/profiles\/5317\/revisions"}],"predecessor-version":[{"id":6044,"href":"https:\/\/oge.mit.edu\/msrp\/wp-json\/wp\/v2\/profiles\/5317\/revisions\/6044"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/oge.mit.edu\/msrp\/wp-json\/wp\/v2\/media\/5616"}],"wp:attachment":[{"href":"https:\/\/oge.mit.edu\/msrp\/wp-json\/wp\/v2\/media?parent=5317"}],"wp:term":[{"taxonomy":"profile_category","embeddable":true,"href":"https:\/\/oge.mit.edu\/msrp\/wp-json\/wp\/v2\/profile_category?post=5317"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}