{"id":5317,"date":"2026-05-13T14:59:53","date_gmt":"2026-05-13T18:59:53","guid":{"rendered":"https:\/\/oge.mit.edu\/msrp\/?post_type=profiles&#038;p=5317"},"modified":"2026-08-13T14:42:38","modified_gmt":"2026-08-13T18:42:38","slug":"angela-milo","status":"publish","type":"profiles","link":"https:\/\/oge.mit.edu\/msrp\/profiles\/angela-milo\/","title":{"rendered":"Angela Milo"},"content":{"rendered":"<div class=\"wp-block-image\">\n<figure class=\"alignleft size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"400\" height=\"599\" src=\"https:\/\/oge.mit.edu\/msrp\/wp-content\/uploads\/sites\/2\/2026\/05\/Milo-Angela.jpg\" alt=\"by Corban Swain\" class=\"wp-image-5616\" style=\"aspect-ratio:1;object-fit:cover;width:200px;height:auto\" srcset=\"https:\/\/oge.mit.edu\/msrp\/wp-content\/uploads\/sites\/2\/2026\/05\/Milo-Angela.jpg 400w, https:\/\/oge.mit.edu\/msrp\/wp-content\/uploads\/sites\/2\/2026\/05\/Milo-Angela-200x300.jpg 200w\" sizes=\"auto, (max-width: 400px) 100vw, 400px\" \/><\/figure>\n<\/div>\n\n\n<div class=\"wp-block-group\"><div class=\"wp-block-group__inner-container is-layout-constrained wp-block-group-is-layout-constrained\">\n<p class=\"wp-block-paragraph\"><strong>Harvey Mudd College<\/strong><br>Faculty Advisor: Prof. Mo Movassaghi<br>Research Supervisors: Angel Garcia-Ramirez,<br>Kathleen Downey<br>Department: Chemistry<\/p>\n<\/div><\/div>\n\n\n\n<div style=\"height:0px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>Biography<\/strong><\/h4>\n\n\n\n<p class=\"wp-block-paragraph\">Angela Milo is a rising junior at Harvey Mudd College studying chemistry. She is<br>motivated by the challenge of developing reactions that are efficient and environmentally<br>responsible. At Harvey Mudd, she explored greener solvents for teaching laboratory<br>experiments with Professor Vosburg. In the summer of 2025, she was a Leadership Alliance<br>Summer Undergraduate Research Fellow at Princeton University, where she worked on<br>photothermal methods to degrade polymers with Professor Stache. In Professor Ball\u2019s lab at<br>Pomona College, she studies click reactions to access pharmaceutically relevant structures<br>through sulfur-fluoride exchange chemistry. This summer, in Professor Movassaghi\u2019s lab, she<br>is synthesizing epidithiodiketopiperazines, a class of biologically active natural products. Her<br>research experience spans organic synthesis, catalysis, and green chemistry. She has been<br>recognized as a 2026 Astronaut Scholar and a 2024 American Chemical Society Scholar. On<br>campus, she is involved as a teaching assistant, tutor, and serves on the student government as<br>sustainability coordinator.<\/p>\n\n\n\n<p class=\"has-text-align-center wp-block-paragraph\"><br><strong>Synthesis of Diastereomerically Enriched Epidithiodiketopiperazines<br>Angela Milo1, Angel Garcia-Ramirez2 and Mohammad Movassaghi2<\/strong><br>1Department of Chemistry, Harvey Mudd College<br>2Department of Chemistry, Massachusetts Institute of Technology<\/p>\n\n\n\n<p class=\"has-text-align-center wp-block-paragraph\"><br>Epidithiodiketopiperazines (ETPs) are a class of structurally complex natural products<br>with diverse biological activities, including potent anticancer properties. Efficient access<br>to stereochemically defined ETP derivatives remains important for enabling biological<br>evaluation. Herein, we describe progress toward the synthesis of diastereomerically enriched<br>C4-substituted ETPs through the development and scale-up of a concise synthetic route. The<br>sequence features silyl protection, lactamization, oxidation, silylation, and sulfidation. This<br>work has established a practical route to gram-scale quantities of ETP intermediates, with<br>ongoing efforts focused on completing the synthesis of the target compounds and enabling<br>future biological studies.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n","protected":false},"featured_media":5616,"template":"","profile_category":[25],"class_list":["post-5317","profiles","type-profiles","status-publish","has-post-thumbnail","hentry","profile_category-2026-interns"],"acf":[],"_links":{"self":[{"href":"https:\/\/oge.mit.edu\/msrp\/wp-json\/wp\/v2\/profiles\/5317","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/oge.mit.edu\/msrp\/wp-json\/wp\/v2\/profiles"}],"about":[{"href":"https:\/\/oge.mit.edu\/msrp\/wp-json\/wp\/v2\/types\/profiles"}],"version-history":[{"count":3,"href":"https:\/\/oge.mit.edu\/msrp\/wp-json\/wp\/v2\/profiles\/5317\/revisions"}],"predecessor-version":[{"id":5828,"href":"https:\/\/oge.mit.edu\/msrp\/wp-json\/wp\/v2\/profiles\/5317\/revisions\/5828"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/oge.mit.edu\/msrp\/wp-json\/wp\/v2\/media\/5616"}],"wp:attachment":[{"href":"https:\/\/oge.mit.edu\/msrp\/wp-json\/wp\/v2\/media?parent=5317"}],"wp:term":[{"taxonomy":"profile_category","embeddable":true,"href":"https:\/\/oge.mit.edu\/msrp\/wp-json\/wp\/v2\/profile_category?post=5317"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}