Engineering the molecular design of intelligent biomaterials by controlling structure, recognition and specificity is the first step in coordinating and duplicating complex biological and physiological processes. Recent developments in siRNA and protein delivery have been directed towards the preparation of targeted formulations for protein delivery to specific sites, use of environmentally-responsive polymers to achieve pH- or temperature-triggered delivery, usually in modulated mode, and improvement of the behavior of their mucoadhesive behavior and cell recognition. We address design and synthesis characteristics of novel crosslinked networks capable of protein release as well as artificial molecular structures capable of specific molecular recognition of biological molecules. Molecular imprinting and microimprinting techniques, which create stereo-specific three-dimensional binding cavities based on a biological compound of interest can lead to preparation of biomimetic materials for intelligent drug delivery, drug targeting, and tissue engineering. We have been successful in synthesizing novel glucose- and protein-binding molecules based on non-covalent directed interactions formed via molecular imprinting techniques within aqueous media. We have also developed structurally superior materials to serve as effective carriers for siRNA delivery to combat Crohn disease and ulcerative colitis.
Nicholas Peppas, Sc.D. is the Cockrell Family Regents Chair in Engineering #6 Professor, McKetta Department of Chemical Engineering, Department of Biomedical Engineering, Department of Surgery and Perioperative Care, Dell Medical School, and Division of Pharmaceutics, College of Pharmacy Director, Institute for Biomaterials, Drug Delivery and Regenerative Medicine at the University of Texas at Austin. Join us in E25-111 at 4:30 PM, Thursday, March 3, 2016. More information about Dr. Peppas.