Kamath: Tackling cancer research from multiple perspectives


November 20, 2015

As an MIT undergraduate, Tushar Kamath regularly rode his bike across the Charles River to Massachusetts General Hospital (MGH) to retrieve blood samples from cancer patients; he then analyzed these samples on campus, at the Koch Institute for Integrative Cancer Research. Kamath, who received his BS in biological engineering in June and is now an MIT master’s student in biological engineering, says his trips back and forth across the river reflect his interdisciplinary view of research.

The blood that Kamath pedaled back from MGH helped in an exciting discovery about circulating tumor cells, which move through the blood in very low numbers, making them difficult to capture: He determined that a method of capturing these cells, developed in the lab where he was working, was as good as the method approved by the Food and Drug Administration. The experience showed Kamath that you don’t need a PhD to make a significant discovery.

Kamath is working with William Thilly, a professor of biological engineering at MIT, and research scientist Elena Gostjeva in the new field of metakaryotic biology. Gostjeva discovered the metakaryotic stem cells, which create organs during fetal and juvenile growth, but later serve as the generative stem cells for pathologic lesions including tumors and atherosclerotic plaques. These cells also have peculiarities including X-ray resistance, not using mitosis to divide, and organizing their genomes in a set of circular structures instead of in linear chromosomes. Read more at MIT News.

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