The immune system is a complex network of many different cells working together to defend against invaders. Successfully fighting off an infection depends on the interactions between these cells. A new device developed by MIT engineers offers a much more detailed picture of that cellular communication. Using this device, which captures pairs of cells and collects data on each as they interact with each other, the researchers have already learned more about how T cells — major players in the immune response — become activated during infection.
The device is based on microfluidic technology developed by Joel Voldman, an MIT professor of electrical engineering and computer science (EECS), in 2009. His team used that earlier version to fuse adult cells with embryonic stem cells, allowing the researchers to observe the genetic reprogramming that occurred in these hybrids. Read more at MIT News, as graduate student and lead author on the new paper, Burak Dura, talks about her research.