Our DNA is under constant attack from many sources, including environmental pollutants, ultraviolet light, and radiation. Fortunately, cells have several major DNA repair systems that can fix this damage, which may lead to cancer and other diseases if not mended.
The effectiveness of these repair systems varies greatly from person to person; scientists believe that this variability may explain why some people get cancer while others exposed to similar DNA-damaging agents do not. A team of MIT researchers has now developed a test that can rapidly assess several of these repair systems, which could help determine individuals’ risk of developing cancer and help doctors predict how a given patient will respond to chemotherapy drugs.
The new test, described in the Proceedings of the National Academy of Sciences the week of April 21, can analyze four types of DNA repair capacity simultaneously, in less than 24 hours. Previous tests have been able to evaluate only one system at a time.
Graduate students Carrie Margulies and Isaac Chaim; technical assistants Siobhan McRee and Patrizia Mazzucato; and research scientists Vincent Butty, Anwaar Ahmad, Ryan Abo, and Anthony Forget also contributed to the research, which was funded by the NIH and NIEHS.
Read the article on MIT news. photo courtesy Aprotim Mazumder